Ameliorative Effects of induced pluripotent stem cells on experimentally induced ovarian ablation in adult female rats

The current study designed to evaluate the role of pluripotent stem cells (iPSc) on experimentally-induced ovarian ablation (OA) by evaluating hematological parameters, FSH and E2 changes, molecular histopathological examination. 50 female rats were divided into five groups with 10 in each group. Group (1): control (2): injected Doxorubicin (DOX) (3 mg/kg) Cyclophosphamide (CYP) (50mg/kg) dissolved sterile physiological saline I/P once a week for 5 weeks. (3): undergo chemoablasion then IU pregnant mare serum gonadotropin (PMSG) single s/c injection. (4): chemoablasion, iPSc i/v injection 2 months. (5): combined PMSG. Results revealed that Dox CYP showed asignificant decrease RBCs, Hb PCV, WBCs, lymphocytes, neutrophil, eosinophil, level Oct 4 while there was significant increase MCV, MCH, monocytes compared (-ve) While, treated PMSG or IPSc RBCs count as well MCHC, non changes eosinophil neutrophil OA group